Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites

Questions this paper answers

Does cyanovirin-N need its disulfide bonds to bind mannosylated peptides?

No. We found that dimannosylated hemagglutinin peptides bind CV-N variants without disulfide bonds, and that an engineered ion pair in place of a disulfide enhanced binding to full-length hemagglutinin (Schilling et al., RSC Adv. 2020, 10, 11079).

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• Publisher version (doi:10.1039/d0ra01128b)
• PubMed 35495330
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How to cite

Schilling, P. E.; Kontaxis, G.; Dragosits, M.; Schiestl, R. H.; Becker, C. F. W.; Maier, I. Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites. RSC Adv. 2020, 10, 11079–11087. https://doi.org/10.1039/d0ra01128b

@article{Schilling2020Mannosylated,
  author = {Schilling, Philipp E. and Kontaxis, Georg and Dragosits, Martin and Schiestl, Robert H. and Becker, Christian F. W. and Maier, Irene},
  title = {{Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites}},
  journal = {RSC Advances},
  volume = {10},
  number = {19},
  pages = {11079--11087},
  year = {2020},
  doi = {10.1039/d0ra01128b},
  url = {https://doi.org/10.1039/d0ra01128b}
}